14 May, 2026

Recent scientific publications have investigated the potential role of zinc in vaginal tissue physiology and vulvovaginal health. A recent systematic review and meta-analysis published in BMC Infectious Diseases evaluated available clinical, observational, and mechanistic studies related to zinc and vulvovaginal candidiasis (VVC).

The review summarized evidence suggesting that women with recurrent vulvovaginal candidiasis may exhibit lower systemic zinc levels compared to healthy controls. Experimental studies discussed in the review also reported that zinc may influence inflammatory pathways and fungal virulence mechanisms associated with vulvovaginal candidiasis.

Additional preclinical studies have demonstrated that zinc may contribute to extracellular matrix physiology in vaginal tissue by influencing collagen and elastin production in human vaginal smooth muscle cells.

These findings contribute to the growing scientific interest in local vaginal zinc delivery approaches and support further investigation of zinc-containing vaginal formulations.. It is open access by clicking here